Nevşehir Hacı Bektaş Veli University Course Catalogue

Information Of Programmes

INSTITUTE OF SCIENCE / MBG525 - MONECULER BIOLOGY AND GENETICS

Code: MBG525 Course Title: MOLECULAR TOXICOLOGY Theoretical+Practice: 3+0 ECTS: 6
Year/Semester of Study 1 / Fall Semester
Level of Course 2nd Cycle Degree Programme
Type of Course Optional
Department MONECULER BIOLOGY AND GENETICS
Pre-requisities and Co-requisites None
Mode of Delivery Face to Face
Teaching Period 14 Weeks
Name of Lecturer ÜMİT KUMBIÇAK (umitkumbicak@nevsehir.edu.tr)
Name of Lecturer(s)
Language of Instruction Turkish
Work Placement(s) None
Objectives of the Course
The aim of this course is to gain knowledge and skills to investigate and investigate the mechanisms of action of toxic substances at molecular level.

Learning Outcomes PO MME
The students who succeeded in this course:
LO-1 can explains the effects of toxic substances on organisms at the molecular level PO-2 Have information about current topics in molecular biology and genetics
PO-3 Ability to identify problems in Molecular Biology and genetics, to establish hypotheses for solving problems and to be able to solve hypothesis using various observational and experimental methods
PO-4 Being ethical and responsible individuals who are sensitive to social and universal values in the field of Molecular Biology and genetics, who look after the priority areas of the country, research and produce and contribute to these issues
PO-7 Investigating the phenotypic effects of genes and acquiring the ability to use this effect in animal and plant breeding areas
PO-8 Ability to participate in interdisciplinary studies in the fields of education, industry, agriculture, health, environment, energy and biotechnology
LO-2 can explain the mechanisms of action of toxic substances on cell organelles, proteins and genome PO-4 Being ethical and responsible individuals who are sensitive to social and universal values in the field of Molecular Biology and genetics, who look after the priority areas of the country, research and produce and contribute to these issues
PO-5 Ability to design a research project in the field of molecular biology and genetics and to evaluate and present the results related to it
PO-8 Ability to participate in interdisciplinary studies in the fields of education, industry, agriculture, health, environment, energy and biotechnology
PO-9 Recognizes and explains the molecular biology and genetics of the problems of other disciplines
PO-10 Read and critically discuss the world-wide literature on molecular biology and molecular genetics
PO-11 Explains the basic functions of scientific processes, critically discusses and solves problems using appropriate statistical and computational methods, chooses contemporary experimental and theoretical approaches that will ultimately lead to the solution of molecular biology and genetic research problems
LO-3 can understand the studies in the field of toxicology. PO-6 Ability to independently carry out an activity that requires expertise in the field
PO-10 Read and critically discuss the world-wide literature on molecular biology and molecular genetics
PO-11 Explains the basic functions of scientific processes, critically discusses and solves problems using appropriate statistical and computational methods, chooses contemporary experimental and theoretical approaches that will ultimately lead to the solution of molecular biology and genetic research problems
PO-12 To be able to transfer current developments and own studies in the field with quantitative and qualitative data to the groups in the field and outside the field in a systematic manner in written, oral and visual form
PO-13 Scientific developments contribute to research and development
PO: Programme Outcomes
MME:Method of measurement & Evaluation

Course Contents
Xenobiotics, ways of entry of toxic substances into the body,  absobtion, distribution and excretion, biotransformation of toxic substances, factors affecting toxicity, mechanisms of toxic effects, teratogenesis, carcinogenesis, genotoxicity, toxicogenomics and toxicoproteomics
Weekly Course Content
Week Subject Learning Activities and Teaching Methods
1 introduction to toxicology Explanation Method
2 Routes of entry of toxic substances into the body, absobtion, distribution and excretion, Explanation Method
3 biotransformation of toxic substances, Explanation Method
4 factors affecting toxicity Explanation Method
5 mechanisms of toxic effects Explanation Method
6 genotoxicity Explanation Method
7 carcinogenesis Explanation Method
8 mid-term exam
9 teratogenesis Explanation Method
10 toxicogenomics Explanation Method
11 toxicoproteomics Explanation Method
12 toxicokinetics Explanation Method
13 Systemic toxicology Explanation Method
14 Molecular toxicology techniques Explanation Method
15 Molecular toxicology techniques Explanation Method
16 final exam
Recommend Course Book / Supplementary Book/Reading
1 Molecular Toxicology-P. David Josephy and Bengt Mannervik
Required Course instruments and materials
Course book, course presentations

Assessment Methods
Type of Assessment Week Hours Weight(%)
mid-term exam 8 1 40
Other assessment methods
1.Oral Examination
2.Quiz
3.Laboratory exam
4.Presentation
5.Report
6.Workshop
7.Performance Project
8.Term Paper
9.Project
final exam 16 2 60

Student Work Load
Type of Work Weekly Hours Number of Weeks Work Load
Weekly Course Hours (Theoretical+Practice) 3 14 42
Outside Class
       a) Reading 3 7 21
       b) Search in internet/Library 4 8 32
       c) Performance Project 4 7 28
       d) Prepare a workshop/Presentation/Report 3 6 18
       e) Term paper/Project 0
Oral Examination 0
Quiz 0
Laboratory exam 0
Own study for mid-term exam 3 6 18
mid-term exam 1 1 1
Own study for final exam 3 6 18
final exam 2 1 2
0
0
Total work load; 180