Nevşehir Hacı Bektaş Veli University Course Catalogue
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| Year/Semester of Study | 1 / Spring Semester | ||||
| Level of Course | 3rd Cycle Degree Programme | ||||
| Type of Course | Optional | ||||
| Department | MOLECULAR BIOLOGY AND GENETICS (PHD) | ||||
| Pre-requisities and Co-requisites | None | ||||
| Mode of Delivery | Face to Face | ||||
| Teaching Period | 14 Weeks | ||||
| Name of Lecturer | ZÜBEYDE KUMBIÇAK (zkumbicak@nevsehir.edu.tr) | ||||
| Name of Lecturer(s) | |||||
| Language of Instruction | Turkish | ||||
| Work Placement(s) | None | ||||
| Objectives of the Course | |||||
| The aim of this course is to provide knowledge and skills on the role of epigenetic mechanisms in the regulation of gene expression and the relationship of epigenetic mechanisms with development and diseases. | |||||
| Learning Outcomes | PO | MME | |
| The students who succeeded in this course: | |||
| LO-1 | can explain the basic concepts related to epigenetic concepts. |
PO-1 Have information about current issues in molecular biology and genetics. PO-2 Obtain basic knowledge of Molecular Biology PO-5 Being ethical and responsible individuals who are sensitive to social and universal values in the field of Molecular Biology and genetics, who look after the priority areas of the country, research and produce and contribute to these issues |
Examination |
| LO-2 | can explain chromatin modifications |
PO-3 Make use of the knowledge they have in order to find a solution to problems by analyzing, comparing and questioning them and can carry out original research in the related field on their own PO-4 Evaluate the knowledge and skills in a critical way in every activity regarding the field, thereby guiding their learning PO-5 Being ethical and responsible individuals who are sensitive to social and universal values in the field of Molecular Biology and genetics, who look after the priority areas of the country, research and produce and contribute to these issues |
Examination |
| LO-3 | can explain histones and histone modifications |
PO-1 Have information about current topics in molecular biology and genetics PO-2 Obtain basic knowledge of Molecular Biology PO-3 Scientific developments contribute to research and development |
Examination |
| LO-4 | can explain genomic imprinting and X-inactivation. |
PO-4 Evaluate the knowledge and skills in a critical way in every activity regarding the field, thereby guiding their learning |
Examination |
| LO-5 | can explain the molecular mechanisms of epigenetics |
PO-4 Evaluate the knowledge and skills in a critical way in every activity regarding the field, thereby guiding their learning |
Examination |
| LO-6 | can discuss the effect of micro and macro environment on epigenetic changes. |
PO-6 Ability to design a research project in the field of molecular biology and genetics and to evaluate and present the results related to it |
Examination |
| LO-7 | can explain the role of epigenetic factors in developmental biology |
PO-4 Evaluate the knowledge and skills in a critical way in every activity regarding the field, thereby guiding their learning PO-6 Ability to design a research project in the field of molecular biology and genetics and to evaluate and present the results related to it |
Examination |
| LO-8 | can explain epigenetic analysis methods. |
PO-1 Have information about current issues in molecular biology and genetics. PO-6 Ability to design a research project in the field of molecular biology and genetics and to evaluate and present the results related to it |
Examination |
| LO-9 | can explain the importance of epigenetic programming in stem cell biology |
PO-1 Have information about current topics in molecular biology and genetics PO-2 Obtain basic knowledge of Molecular Biology PO-3 Scientific developments contribute to research and development |
Examination |
| LO-10 | can explain the relationship between epigenetics and diseases through examples |
PO-1 Have information about current topics in molecular biology and genetics PO-2 Obtain basic knowledge of Molecular Biology PO-3 Scientific developments contribute to research and development |
Examination |
| PO: Programme Outcomes MME:Method of measurement & Evaluation |
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| Course Contents | ||
| Epigenetic concepts, Chromatin modifications, Histones and histone modifications, DNA methylation, genomic imprinting, X-inactivation, molecular mechanisms of epigenetics, the effects of micro and macro environment on epigenetic changes, epigenetic factors in developmental biology, analysis methods of epigenetics, stem cell biology and epigenetic programming, epigenetics and diseases, cancer epigenetics, epigenetic therapy concept | ||
| Weekly Course Content | ||
| Week | Subject | Learning Activities and Teaching Methods |
| 1 | epigenetic concepts, | Explanation Method |
| 2 | Chromatin modifications, | Explanation Method |
| 3 | Histones and histone modifications, | Explanation Method |
| 4 | DNA methylation, | Explanation Method |
| 5 | Genomic imprinting, X-inactivation, | Explanation Method |
| 6 | Molecular mechanisms of epigenetics, | Explanation Method |
| 7 | The effect of micro and macro environment on epigenetic changes, | Explanation Method |
| 8 | mid-term exam | |
| 9 | Epigenetic factors in developmental biology, | Explanation Method |
| 10 | Epigenetic analysis methods, | Explanation Method |
| 11 | Stem cell biology and epigenetic programming, | Explanation Method |
| 12 | Epigenetics and diseases, | Explanation Method |
| 13 | cancer epigenetics, | Explanation Method |
| 14 | Epigenetic therapy concept | Explanation Method |
| 15 | Epigenetic approaches in other organisms | Explanation Method |
| 16 | final exam | |
| Recommend Course Book / Supplementary Book/Reading | ||
| 1 | Epigenetics, C. David Allis, Thomas Jenuwein, Danny Reinberg, Marie-Laure Caparros. Cold Spring Harbour Laboratory Press, New York, 2007 | |
| 2 | Epigenetics and Chromatin (Progress in MolecularAndSubcellularBiology).PhilippeJeanteur (Editor), SpringerPress, New York, 2008 | |
| Required Course instruments and materials | ||
| Course book and presentations | ||
| Assessment Methods | |||
| Type of Assessment | Week | Hours | Weight(%) |
| mid-term exam | 8 | 1 | 40 |
| Other assessment methods | |||
| 1.Oral Examination | |||
| 2.Quiz | |||
| 3.Laboratory exam | |||
| 4.Presentation | |||
| 5.Report | |||
| 6.Workshop | |||
| 7.Performance Project | |||
| 8.Term Paper | |||
| 9.Project | |||
| final exam | 16 | 2 | 60 |
| Student Work Load | |||
| Type of Work | Weekly Hours | Number of Weeks | Work Load |
| Weekly Course Hours (Theoretical+Practice) | 3 | 14 | 42 |
| Outside Class | |||
| a) Reading | 5 | 8 | 40 |
| b) Search in internet/Library | 5 | 8 | 40 |
| c) Performance Project | 0 | ||
| d) Prepare a workshop/Presentation/Report | 0 | ||
| e) Term paper/Project | 0 | ||
| Oral Examination | 0 | ||
| Quiz | 0 | ||
| Laboratory exam | 0 | ||
| Own study for mid-term exam | 5 | 5 | 25 |
| mid-term exam | 1 | 1 | 1 |
| Own study for final exam | 5 | 6 | 30 |
| final exam | 2 | 1 | 2 |
| 0 | |||
| 0 | |||
| Total work load; | 180 | ||