| Learning Outcomes |
PO |
MME |
| The students who succeeded in this course: |
|
|
| LO-1 |
can explain the molecular biomarker types. |
PO-1 Have information about current issues in molecular biology and genetics.
PO-2 Obtain basic knowledge of Molecular Biology
|
Examination
|
| LO-2 |
Gains knowledge about the use of biomarkers in medicine. |
PO-6 Ability to design a research project in the field of molecular biology and genetics and to evaluate and present the results related to it
|
Examination
|
| LO-3 |
Can plan a research related to the discovery of biomarkers. |
PO-3 Make use of the knowledge they have in order to find a solution to problems by analyzing, comparing and questioning them and can carry out original research in the related field on their own
PO-6 Ability to design a research project in the field of molecular biology and genetics and to evaluate and present the results related to it
|
Examination
|
| LO-4 |
can follow and convey the developments in the field of molecular medicine. |
PO-1 Have information about current issues in molecular biology and genetics.
|
Examination
|
PO: Programme Outcomes
MME:Method of measurement & Evaluation |
| Course Contents |
| The concept and types of molecular biomarkers, the use of biomarkers in medicine in diagnosis and prognosis, the discovery and identification processes of biomarkers, the functional importance of biomarkers, the importance of omics technologies in biomarker discovery, biomarkers and personalized medicine. |
| Weekly Course Content |
| Week |
Subject |
Learning Activities and Teaching Methods |
| 1 |
Molecular medicine and biomarker concepts. |
Lecture, Discussion, Question Answer, Literature Search |
| 2 |
Types and sources of molecular biomarkers. |
Lecture, Discussion, Question Answer, Literature Search |
| 3 |
Importance and usage areas of biomarkers in medicine. |
Lecture, Discussion, Question Answer, Literature Search |
| 4 |
Methods used in the discovery of biomarkers I: Genomics & Transcriptomics |
Lecture, Discussion, Question Answer, Literature Search |
| 5 |
Methods used in the discovery of biomarkers II: Proteomics |
Lecture, Discussion, Question Answer, Literature Search |
| 6 |
Methods used in the discovery of biomarkers III: Metabolomics |
Lecture, Discussion, Question Answer, Literature Search |
| 7 |
Biomarker validation. |
Lecture, Discussion, Question Answer, Literature Search |
| 8 |
mid-term exam |
|
| 9 |
The process from discovery to clinical use of biomarkers. |
Lecture, Discussion, Question Answer, Literature Search |
| 10 |
Examples of the use of biomarkers for diagnostic purposes in medicine. |
Lecture, Discussion, Question Answer, Literature Search, Case Study |
| 11 |
Examples of the use of biomarkers for prognostic purposes in medicine. |
Lecture, Discussion, Question Answer, Literature Search, Case Study |
| 12 |
Biomarkers in cancer. |
Lecture, Discussion, Question Answer, Literature Search |
| 13 |
Use of biomarkers in personalized medicine. |
Lecture, Discussion, Question Answer, Literature Search |
| 14 |
Detection of biomarkers in routine clinical practice. |
Lecture, Discussion, Question Answer, Literature Search |
| 15 |
Use of bioinformatics in biomarker research. |
Lecture, Discussion, Question Answer, Literature Search |
| 16 |
final exam |
|
| Recommend Course Book / Supplementary Book/Reading |
| 1 |
Atukeren, P., Uzun, H. (Eds.) (2022). Biomarkers in Medicine. Bentham Books. |
| Required Course instruments and materials |
| Lecture notes, books, related articles |
